MCR was found to be associated with incident cognitive impairment and dementia.
MCR was also found to be associated with low grey matter volume involving the premotor and the prefrontal cortex, and lacunar lesions in the frontal lobe
however, no significant associations with white matter abnormality were found. Its significant association with both low brain grey matter volume and lacunar lesions make MCR’s physiopathology unclear.
MCR successfully predicts cognitive impairment including dementia, suggesting that it may be used as a screening tool for dementia in a primary care setting.