Brain GM volumes of right middle frontal and precentral gyri were positively associated with gait speed in CHI (i.e. slow gait speed was associated with low GM volumes). Striatum (i.e. left putamen and bilateral caudate nuclei) volumes were positively associated with gait speed in patients with MCI. The right middle frontal gyrus volume covaried with cortical frontal region volume in CHI, whereas the left putamen volume covaried with the left putamen and the right caudate nucleus volumes in patients with MCI. Additionally, in patients with MCI the right caudate nucleus was associated with the different volumes of the right caudate nucleus, right frontal regions and the left superior medial frontal gyrus.
Slow gait speed was associated with low brain volumes, and solicited a network of GM regions in the frontal cortex in CHI and the striatum in MCI.