In 2001, Canada was the first country in the world to allow the use of medical cannabis (i.e., a broad term which encompasses the use of cannabis for therapeutic purposes) also known as medicinal marijuana. More recently, new Canadian legalization was enacted which governs the use of cannabis for recreational purpose, leading Canada to become the second country to legalize marijuana after Uruguay. This recent foray into legalization led cannabis back to the medical prescription pad for physicians. There is increasing scientific data suggesting that cannabis could be beneficial for a large range of medical conditions. Physicians must be well aware of related medical knowledge (i.e., indications, dose and safety properties) before prescribing cannabis to older patients who are a priori more prone to adverse cannabis effects, when compared to younger patients. A mini-review was conducted to examine evidence relative to medical cannabis use in older patients.